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| 1 | Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico显示文摘Liver cirrhosis(LC) is a chronic illness caused by inflammatory responses and progressive fibrosis. Globally, the most common causes of chronic liver disease include persistent alcohol abuse, followed by viral hepatitis infections and nonalcoholic fatty liver disease. However, regardless of the etiological factors, the susceptibility and degree of liver damage may be influenced by genetic polymorphisms that are associated with distinct ethnic and cultural backgrounds. Consequently, metabolic genes are influenced by variable environmental lifestyle factors, such as diet, physical inactivity, and emotional stress, which are associated with regional differences among populations. This Topic Highlight will focus on the genetic and environmental factors that may influence the metabolism of alcohol and nutrients in the setting of distinct etiologies of liver disease. The interaction between genes and environment in the current-day admixed population, Mestizo and Native Mexican, will be described. Additionally, genes involved in immune regulation, insulin sensitivity, oxidative stress and extracellular matrix deposition may modulate the degree of severity. In conclusion, LC is a complex disease. The onset, progression, and clinical outcome of LC among the Mexican population are influenced by specific genetic and environmental factors. Among these are an admixed genome with a heterogenic distribution of European, Amerindian and African ancestry; a high score of alcohol consumption; viral infections; a hepatopathogenic diet; and a high prevalence of obesity. The variance in risk factors among populations suggests that intervention strategies directed towards the prevention and management of LC should be tailored according to such population-based features. | Omar Ramos-Lopez Erika Martinez-Lopez Sonia Roman Nora A Fierro Arturo Panduro | 2015 | World Journal of Gastroenterology2015，21，41： | 11 |
| 2 | A low steadyHBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: asystematic review显示文摘 | Roman S Panduro A Aguilar-Gutierrez Y | 2009 | Hepatol Int2009，3，2： | 1 |
| 3 | A comparison of genetic algorithms, particle swarm optimization and the differ- ential evolution method for the design of scannable circular anten- na arrays显示文摘 | Panduro M A Brizuela C A Balderas L I | 2009 | Progress in Electromagnetics Research B2009，13，： | 1 |
| 4 | Hepatic apolipoprotein A-Ⅰ gene expression in patients with cholesterol gallstones treated with ursodeoxycholic acid显示文摘 | Mendez-Sanchez N Panduro A Murguia D | 2002 | Ann Hepatol2002，1，2： | 1 |
| 5 | Hepatitis E virus: An ancient hidden enemy in Latin America显示文摘 | Nora A Fierro Mauricio Realpe Tzintli Meraz-Medina Sonia Roman Arturo Panduro | 2016 | World Journal of Gastroenterology2016，，07： | 1 |
| 6 | Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population:unusual high frequency of CYP2E1*c2 allele显示文摘 | Gordillo-Bastidas Panduro A Gordillo-Bastidas D | 2010 | Alcoholism2010，34，1： | 1 |
| 7 | Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele显示文摘BACKGROUND Cholesterol is related to improvements in the rate of sustained virological response and a robust immune response against the hepatitis C virus(HCV).APOE gene polymorphisms regulate cholesterol levels modifying the course of the HCV infection.The relationship between cholesterol,APOE alleles,and the outcome of HCV infection has not been evaluated in the admixed population of Mexico.AIM To investigate the role of APOE-ε2,-ε3,and-ε4 alleles and the metabolic profile in the outcome of HCV infection.METHODS A total of 299 treatment-na?ve HCV patients were included in this retrospective study.Patients were stratified in chronic hepatitis C(CHC)(n=206)and spontaneous clearance(SC)(n=93).A clinical record was registered.Biochemical tests were assessed by dry chemistry assay.APOE genotypes were determined using a Real-Time polymerase chain reaction assay.RESULTS Total cholesterol,low-density lipoprotein cholesterol(LDL-c),triglycerides,and hypercholesterolemia were higher in SC than CHC patients as well as the frequency of the APOEε4 allele(12.4%vs 7.3%).SC patients were overweight(54.8%).Theε4 allele was associated with SC(OR=0.55,95%CI:0.31-0.98,P=0.042)and mild fibrosis(F1-F2)in CHC patients(OR 0.091,95%CI 0.01-0.75,P=0.020).LDL-c≥101.5 mg/dL(OR=0.20,95%CI:0.10-0.41,P<0.001)and BMI≥26.6 kg/m2(OR=0.37,95%CI:0.18-0.76,P<0.001)were associated with SC status;while ALT≥50.5 IU/L was negatively associated(OR=5.67,95%CI:2.69-11.97,P<0.001).CONCLUSION In SC patients,the APOEε4 allele and LDL-c conferred a protective effect in the course of the HCV infection in the context of excess body weight. | Karina Gonzalez-Aldaco Sonia Roman Rafael Torres-Valadez Claudia Ojeda-Granados Luis A Torres-Reyes Arturo Panduro | 2019 | World Journal of Gastroenterology2019，25，38： | 1 |
| 8 | CD36 genetic variation, fat intake and liver fibrosis in chronic hepatitis C virus infection显示文摘AIM To analyze the association of the CD36 polymorphism(rs1761667) with dietary intake and liver fibrosis(LF) in chronic hepatitis C(CHC) patients. METHODS In this study, 73 patients with CHC were recruited. The CD36 genotype(G > A) was determined by a TaqM an real-time PCR system. Dietary assessment was carried out using a three-day food record to register the daily intake of macronutrients. Serum lipids and liver enzymes were measured by a dry chemistry assay. LF evaluated by transient elastography(Fibroscan~)and APRI score was classified as mild LF(F1-F2) and advanced LF(F3-F4).RESULTS Overall, the CD36 genotypic frequencies were AA(30.1%), AG(54.8%), and GG(15.1%), whereas the allelic A and G frequencies were 57.5% and 42.5%, respectively. CHC patients who were carriers of the CD36 AA genotype had a higher intake of calories attributable to total fat and saturated fatty acids than those with the non-AA genotypes. Additionally, aspartate aminotransferase(AST) serum values were higher in AA genotype carriers compared to non-AA carriers(91.7 IU/L vs 69.8 IU/L, P = 0.02). Moreover, the AA genotype was associated with an increase of 30.23 IU/L of AST(β = 30.23, 95%CI: 9.0-51.46, P = 0.006). Likewise, the AA genotype was associated with advanced LF compared to the AG(OR = 3.60, 95%CI: 1.16-11.15, P = 0.02) or AG + GG genotypes(OR = 3.52, 95%CI: 1.18-10.45, P = 0.02).CONCLUSION This study suggests that the CD36(rs1761667) AA genotype is associated with higher fat intake and more instances of advanced LF in CHC patients. | Omar Ramos-Lopez Sonia Roman Erika Martinez-Lopez Nora A Fierro Karina Gonzalez-Aldaco Alexis Jose-Abrego Arturo Panduro | 2016 | World Journal of Hepatology2016，8，25： | 1 |
| 9 | Rapid and efficient detection of extra-pulmonary Mycobacterium tuberculosis by PCR analysis显示文摘 | Portillo-Gomez L Morris SL Panduro A | 2000 | Int J Tuberc Lung Dis2000，4，4： | 1 |
| 10 | Immunologic, metabolic and genetic factors in hepatitis C virus infection显示文摘The mechanisms that regulate disease progression during hepatitis C virus(HCV)infection and the response to treatment are not clearly identified.Numerous studies have demonstrated that a strong host immune response against HCV favors HCV clearance.In addition,genetic factors and metabolic machinery,particularly cholesterol modulation,are involved in HCV infection.It is likely that the interplay between all of these factors contributes to the outcome of HCV infection.In recent years,the world has experienced its largest epidemic of obesity.Mexico and the United States are the leading sufferers from this epidemic at the global level.Obesity is associated with the development ofnumerous pathologies including hypercholesterolemia which is one of the eight most important risk factors for mortality in Mexico.This may be related to the course of HCV infection in this population.Here,we focus on the urgent need to study the progression of HCV infection in relation to ethnic characteristics.Discoveries are discussed that hold promise in identifying immune,metabolic and genetic factors that,in conjunction,could be therapeutic targets or predictors of the progression of HCV infection. | Nora A Fierro Karina Gonzalez-Aldaco Rafael Torres-Valadez Erika Martinez-Lopez Sonia Roman Arturo Panduro | 2014 | World Journal of Gastroenterology2014，20，13： | 1 |
| 11 | A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review 显示文摘 | ROMAN S PANDURO A AGUILAR-GUTIERREZ Y | 2009 | Hepatol Int2009，3，2： | 1 |
| 12 | Effect of Breathwalk on body composition,metabolic and mood state in chronic hepatitis C patients with insulin resistance syndrome显示文摘瞄准:识别人体测量,新陈代谢并且在丙肝病毒(HCV ) 的心情状态从墨西哥并且到的西方感染了病人评估效果 Breathwalk (BW ) ,走的联合,同步 breathing 和集中的注意,在那些病人上。方法:在试验性的研究,有 HCV 的血清学、分子的诊断的 17 个病人,不接受药理学治疗,被学习。BW 的一个小时会议在星期被练习 3 次六个月。身体作文被电的阻抗估计。生物化学的侧面和抗胰岛素性(红外) 冒的风险被常规方法估计。心情状态在开始并且在节目的结束与特定、待研究的问题被评估。结果:百分之七十个病人超重或肥胖,并且 77% 病人在学习的开始与红外介绍了。改进在第三瞬间被观察,并且统计上,有效差量用健康分数在 第6 瞬间被记录( 76 对 83 , P <
0.01 ),在丙氨酸 aminotransferase (中高音)( 106 +/- 93 U/L 对 59 +/- 32 U/L , P <
0.01 ),全部的胆红素( 0.09 +/- 1 mg/dL 对 0.62 +/- 0.2 mg/dL , P <
0.01 ),中高音/著名计算机生产厂商比率( 1.04 对 0.70 , P <
0.01 ), triglycerides ( 165 +/- 86 mg/dL 对 124 +/- 49 mg/dL , P <
0.01 )并且 IR 风险( 4.0 对 2.7 )。大多数病人(88%) 显示了感觉到擅长 BW 的结束(P <
0.01 ) 。结论:Breathwalk 在身体作文,类脂化合物侧面和肝酶上有重要效果。它也是容易的,便宜并且穿上有益的效果新陈代谢并且在 HCV 病人的心情状态。 | M Vázquez-Vandyck S Roman JL Vázquez L Huacuja G Khalsa R Troyo-Sanromán A Panduro | 2007 | World Journal of Gastroenterology2007，13，46： | 1 |
| 13 | The Response of Hepatic Acute Phase Proteins during Experimental Pulmonary Tuberculosis显示文摘 | Hern ndez-Pando R Arriaga AK Panduro C A | 1998 | Experimental and Molecular Pathology1998，65，1： | 1 |
| 14 | Rapid and efficient detection of extra-pulmonary Mycobacterium tuberculosis by PCR analysis显示文摘 | Portillo-Gomez L Morris SL Panduro A | 2000 | Int J Tuberc Lung Dis2000，4，4： | 1 |
| 15 | A trade off curve computation for linear antenna ar rays using an evolutionary muhi-objective approach 显示文摘 | Panduro M A grizue Covarrubias D | 2006 | Soft Computing- A Fusion of Foundations Methodologies and Applications2006，10，2： | 1 |
| 16 | A multi-objective approach in lhe linear antenna array design 显示文摘 | Panduro M A Covarrubias D H Brizuela C A | 2005 | AEU-lnternational Journal of Elec- tronics and Communications2005，59，4： | 1 |
| 17 | Low prevalence of anti-hepatitis C virus antibodies in Mexico:a sestematic review显示文摘 | Chiquete E Panduro A | 2007 | Intervirology2007，50，1： | 1 |
| 18 | Distri-bution of HBV genotypes F and H in Mexico and Central Ameri-ca显示文摘 | Panduro A Maldonado-Gonzalez M Fierro NA | 2013 | Antivir Ther2013，18，3： | 1 |
| 19 | Albumin gene expression is down-regulated by albu- min or macromoleeule infusion in the rat显示文摘 | Pietrangelo A Panduro A Chowdhury J R | 1992 | Jour- nal of Clinical Investigation1992，89，6： | 1 |
| 20 | High prevalence of occult hepatitis B virus genotype H infection among children with clinical hepatitis in west Mexico显示文摘 | Escobedo-Melendez G Panduro A Fierro NA | 2014 | Mem Inst Oswaldo Cruz2014，109，6： | 1 |
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