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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | The ica operon and biofilm prodution in coagulase negative staphylococci associated with carriage and disease in a neonatal intensive care unit显示文摘 | de SILVA G D KANTZANOU M JUSTICE A | 2002 | J Clin Microbiol2002，40，： | 1 |
| 3 | Development of vegetation andsoil indices for MODIS显示文摘 | Huete A Justice C Liu H | 1994 | Remote sensing of environment1994，，49： | 1 |
| 4 | by John Braithwaite显示文摘 | Restortive Justice And A Better Futuer | 1996 | Australian National University Dalhousie University 17 October1996，1996，： | 1 |
| 5 | A binary linear programming for?mulation of the graph edit distance显示文摘 | JUSTICE 0 HERO A O | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，8： | 1 |
| 6 | Air permeability of compacted cohesive soils 显示文摘 | LANGFELDER L J CHEN C F JUSTICE J A | 1968 | Journal of the Irrigation and Drainage Division1968，94，4： | 1 |
| 7 | The ica operon and biofilm production in coagulase-negative staphylococci associated with carriage and disease in a neonatal intensive care unit显示文摘 | De Silva GDI Kantzanou M Justice A | 2002 | J Clin Microbiol2002，40，2： | 1 |
| 8 | Atmospheric correction of MODIS data in the visible to middle infrared: first results显示文摘 | VERMOTE E F SALEOUS N A JUSTICE C O | 2002 | Remote Sensing of Environment2002，83，1： | 1 |
| 9 | Synthesis, characterization, and adsorption properties of nanocrystalline ZSM-5 显示文摘 | SONG W JUSTICE R E JONES C A GRASSIAN V H LARSEN S C | 2004 | Langmuir2004，20，19： | 1 |
| 10 | Developments in the validation' of satellite sensor products for the study of the land surface 显示文摘 | Justice C Belward A Morisette J | 2000 | International Journal of Remote Serving2000，21，17： | 1 |
| 11 | Pre-Schoolers,Print and Storybooks:An Observational Study Using Eye Movement Analysis显示文摘 | JUSTICE L M SKIBBE L CANNING A | 2005 | Journal of Research in Reading2005，28，3： | 1 |
| 12 | Pioneering women in infor- mation science 显示文摘 | Bonnici L J Furner J Justice A | 2003 | Proceedings of the American Society for Infor- mation Science and Technology2003，40，1： | 1 |
| 13 | 3D cell cuhure opens new dimensions in cell-based assays显示文摘 | JUSTICE B A BADR N A FELDER R A | 2007 | Drug Discov Today2007，14，1： | 1 |
| 14 | Peacock the ica operon and biofilm production in coagulase negative staphylococci associated with carriage and disease in a neonatal intensive care unit显示文摘 | G D I de Silva M Kantzanou A Justice | 2002 | J Clin Microbiol2002，40，2： | 1 |
| 15 | Virulera combinations of adhesion and toxin genes in natural populations of Staphylo coccus aureus显示文摘 | Peacock SJ Moore CE Justice A | 2002 | Infeet lmmun2002，70，9： | 1 |
| 16 | Potential global fire monitoring from EOS-MODIS显示文摘 | Kaufman Y J Justice C O Flynn L P Kendall J D Prins E M Giglio L Ward D E Menzel W P & Setzer A W | 1998 | Journal of Geophysical Research1998，103，32： | 1 |
| 17 | Development of Vegetation and Soil Indices for MODIS显示文摘 | Huete A Justice C Liu H | 1994 | Remote Sensing of Environment1994，49，： | 1 |
| 18 | Process controlin cell culture technology using dielectric spectroscopy 显示文摘 | JUSTICE C BRIX A FREIMARK D | 2011 | Biotechnol Adv2011，29，4： | 1 |
| 19 | Virulent combinations of adhesion and toxin genes in natural populations of Staphy- lococcus aureus显示文摘 | Peacock SJ Moore CE Justice A | 2002 | Infect Immun2002，70，9： | 1 |
| 20 | Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions显示文摘 | Caniglia EC Cain LE Justice A | 2014 | Neurology2014，83，2： | 1 |
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