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Fos expression in tyrosine hydroxylase-containing neurons in rat brainstem after visceral noxious stimulation:an immunohistochemical study

查看全文 作　　者：Feng Han Yu-Fei Zhang Yun-Qing Li Department of Anatomy and K.K.Leung Brain Research Centre,the Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China 高影响力作者 出　　处：《World Journal of Gastroenterology》索引2003年第9卷第5期,共6页高影响力期刊 基　　金：Grants-in-Aid from the National Natural Science Foundation of China(Nos.39970239,30070389,3000052);the Foundation for University Key Teacher by the Ministry of Education of China and the National Program of Basic Research of China(G1999054004) 摘　　要：AIM: To prove that neurons in the different structures of the brainstem that express tyrosine hydroxylase (TH) are involved in the transmission and modulation of visceral or somatic nociceptive information in rat.METHODS: Immunohistochemical double-staining method was used to co-localize TH and Fos expression in neurons of the rat brainstem in visceral or subcutaneous noxious stimulation models.RESULTS: Neurons co-expressing TH/Fos were observed in lateral reticular nucleus (LRT), rostroventrolateral reticular nucleus (RVL), solitary tract nucleus (SOL), locus coeruleus (LC), A5, A7 neuronal groups and ventrolateral subdivision of the periaqueductal gray (vlPAG) in both models. But the proportion and number of the double-labeled neurons responding to the two noxious stimuli were significantly different in the LRT, RVL and LC nuclei. The proportion and number of the TH/Fos double-labeled neurons in the visceral pain model were smaller than that in the subcutaneous pain model. However, in the case of SOL, they were similar in the two models.CONCLUSION: Differences of Fos expression in TH immunoreactive neurons in animals after visceral and somatic noxious stimulation indicate that the mechanisms of the transmission and modulation of visceral nociceptive information in the brainstem may be different from that of somatic nociceptive information. 关 键 词：酪氨酸羟化酶链 神经元 脑干 动物实验 内脏损害 免疫组织化学 FOS
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