维普中文期刊产品整合服务

MECHANISM OF PATHOLOGICAL CHANGES OF INTRAVENTRICULAR HEMORRHAGE IN DOGS

查看全文 作　　者：[1]戴炯;[1]李善泉;[1]李骁雄;[1]徐斌斌;[1]熊文浩;[1]王勇;[1]张晓华;[2]沈加林 高影响力作者 机构地区：[1]Department of Neurosurgery, Renji Hospital, SSMU, Shanghai 200001, China;[2]Department of Radiology, Renji Hospital, SSMU, Shanghai 200001 , China高影响力机构 出　　处：《Journal of Shanghai Second Medical University(Foreign Language Edition)》索引2004年第16卷第1期,共6页高影响力期刊 摘　　要：Objective To probe the mechanism of pathological changes of intraventricular hemorrhage (IVH). Methods The evaluation of neurological status, serial CT scans and pathological examination were applied on the canine model of lVH. The ventricular volume and blood clot volume were measured based on the CT images. Results The normal adult canine ventricle tend to be slitlike. After injection, the ventricle was obviously dilated by the blood clot. The linear regression of ventricular volume against blood clot volume was significant in the first week. From then on, however, while the clots continued to shrink, the ventricular volume showed progressive elargement. The clots were lysed completely within 3 to 4 weeks. The linear regression of the degree of ventricular dilatation against the first clot volume was also significant. In the pathological examination ,we found the ependyrnal lining of ventricular system was destroyed and neurons in the subependymal areas developed acidophil necrosis, which was prominent around Sylvian aqueduct. Conclusion Hemorrhagic ventricular dilatation (HVD) is a prominent feature of IVH and also is a strong indicator for poor prognosis. lschemic changes of periventricular neurons in some important structures may be the most direct cause for poor outcome of IVH. It may be induced by periventricular vascular structures compressed by HVD, increased intracranial pressure, cerebral vasospasm and others. 关 键 词：心室内出血 病理机制 形态学 动物实验 CT检查 颅内压 脑血管痉挛
相关文献

参考文献(10)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费