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内皮素和一氧化氮对脓毒性休克实验模型中器官损伤,肠系膜缺血和存活的影响(英文)

查看全文 作　　者：Alper B [1]ISKIT;Oguz [1]GUC 高影响力作者 机构地区：[1]Department of Pharmacology Faculty of Medicine Hacettepe University Ankara 06100 Turkey,Department of Pharmacology Faculty of Medicine Hacettepe University Ankara 06100 Turkey高影响力机构 出　　处：《Acta Pharmacologica Sinica》索引2003年第24卷第10期,共6页高影响力期刊 摘　　要：The development of potent drugs to treat cardiopulmonary failure in sepsis, such as antibiotics and new immunomodulatory therapeutic approaches have not prevented sepsis from being a major health problem. Dysfunction of the vascular endothelium is an early event in septic shock. The recognition of endothelium-derived substances, such as nitric oxide and endothelin, important mediators of systemic inflammatory response syndrome,led to the proposal that pharmacological inhibition of nitric oxide and endothelin production could represent a useful strategy in the treatment of septic shock. Splanchnic ischemia and translocation of endotoxin from the gut to the circulation contributes significantly to the high mortality rate in sepsis-related syndromes. This vasoconstriction in the splanchnic circulation can be partially blocked by inducible nitric oxide synthase inhibitor aminoguanidine or endothelin receptor antagonist bosentan in experimental models of septic shock. It can be suggested that endothelin and nitric oxide may affect survival. Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy. The inhibition of nitric oxide production during hyperdynamic,earlier phase of sepsis combined with the blockade of endothelin receptors at a later stage during the hypodynamic,late phase appears to be a novel promising strategy for the therapy of septic shock. The aim of this review is to discuss the role of nitric oxide and endothelin in sepsis and the potential therapeutic implications of blockade of nitric oxide and endothelin as a target in treatment of human septic shock. Briefly the importance of timing of intervention is also emphasized. 关 键 词：内皮素 一氧化氮 脓毒性休克 动物模型 器官损伤 肠系膜缺血
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