Histopathological Study of Trabeculum after Excimer Laser Trabeculectomy ab Interno

查看全文 作　　者：Shengsong Huang,Minbin Yu,Guangqiang Feng,Ping Zhang,Changyu QiuZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060 , China 出　　处：《Eye Science》索引2001年第17卷第1期,共5页 摘　　要：Purpose: To study the clinical manifestations and histopathologic changes of trabeculum after excimer laser trabeculectomy ab interno (ELT), and to investigate the mechanisms of ELT in reducing intraocular pressure. Methods : ELT was performed on ten rabbit eves and postoperative responses were documented. Comeoscleral tissue samples were harvested consecutively each week until the 5th postoperative week and these samples were examined under light and electrical microscopy. Results: Mild stimulation signs were present postoperatix'ely in nine of ten eyes, but no serious complications were experienced. Obvious inflammation was observed in one rabbit eye as a result of iris damage during the surgical manipulations. Local kactures on the trabecular meshwork and openings into Schlemm' s canal were detected in all tissue samples under light microscope. Mitochondria were found to be turgescent and dilated like vacuoles and endoplasmic reticula were found to be dilated under electrical microscope in the early postoperative period. Later, all trabecular cells returned normal and no fihroblast cells were ever detected. Conclusions: Permanent openings through trabecular meshwork into the inner wall of Schlemm's canal can be created with ELT. The outflow resistance of aqueous humor can be reduced with these openings and intraocular pressure can be controlled thereafter. Eye Science 2001; 17:11 ~ 15. 关 键 词：组织病理学 准分子激光疗法 ELT 高眼压 青光眼