Pathogenic analysis of coxsackievirus A10 in rhesus macaques

查看全文 作　　者：Suqin [1]Duan;Fengmei [1]Yang;Yanyan [1]Li;Yuan [1]Zhao;Li [1]Shi;Meng [2]Qin;Quan [1]Liu;Weihua [1]Jin;Junbin [1]Wang;Lixiong [1]Chen;Wei [1]Zhang;Yongjie [1]Li;Ying [1]Zhang;Jingjing [1]Zhang;Shaohui [1]Ma;Zhanlong [1]He;Qihan [1]Li

机构地区：[1]Institute of Medical Biology,Chinese Academy of Medical Sciences&Peking Union Medical College,Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease,Kunming,650118,China;[2]Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology,Beijing University of Chemical Technology,Beijing,100029,China

出　　处：《Virologica Sinica》索引2022年第37卷第4期,共9页

基　　金：the Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences(CIFMS,2016-I2M-2-001);National Resource Center for Non-Human Primates,Major Science and Technology Special Projects in Yunnan Province;Kunming Science and Technology Innovation and Service Capacity Enhancement Program Key Projects(2016-2-R-07674)。 摘　　要：Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particularly young children,may have different immunological responses to infection.Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.The characteristics of CV-A10 infection,replication,and shedding in humans remain unknown.In this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in humans.The clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in humans.Substantial inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and kidney.During the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery period.In addition,there were no significant differences between respiratory and digestive tract infected animals.Overall,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies. 关键词：Coxsackievirus A10(CV-A10) HAND Foot and mouth disease(HFMD) Non-human primate model Rhesus macaque Pathogenic analysis

相关文献

参考文献（36）
引证文献（2）
耦合文献（22）

参考文献(36)

引证文献(2)

耦合文献(22)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Pathogenic analysis of coxsackievirus A10 in rhesus macaques

参考文献(36)

引证文献(2)

耦合文献(22)

用户提示