Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy

查看全文 作　　者：Shenwu [1]Zhang;Yuequan [1]Wang;Zhiqiang [1]Kong;Xuanbo [1]Zhang;Bingjun [1]Sun;Han [1]Yu;Qin [2]Chen;Cong [1]Luo;Jin [1]Sun;Zhonggui [1]He

机构地区：[1]Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;[2]Department of Pharmacy,Cancer Hospital of China Medical University,Liaoning Cancer Hospital&Institute,Shenyang 110042,China

出　　处：《Acta Pharmaceutica Sinica B》索引2021年第11卷第11期,共12页

基　　金：supported by Science and Technology Major Project of Liaoning(No.2019JH1/10300004,China);the National Natural Science Foundation of China(No.81773656 and 81703451);the Excellent Youth Science Foundation of Liaoning Province(No.2020-YQ-06,China);the China Postdoctoral Science Foundation(No.2020M670794);the Liaoning Revitalization Talents Program(No.XLYC1907129 and XLYC1808017,China)。 摘　　要：Pure drug-assembled nanomedicines(PDANs)are currently under intensive investigation as promising nanoplatforms for cancer therapy.However,poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation.Herein,we report a core-matched nanoassembly of pyropheophorbide a(PPa)for photodynamic therapy(PDT).Pure PPa molecules are found to self-assemble into nanoparticles(NPs),and an amphiphilic PEG polymer(PPaPEG_(2K))is utilized to achieve core-matched PEGylating modification via the p-p stacking effect and hydrophobic interaction between the PPa core and the PPa-PEG_(2K) shell.Compared to PCL-PEG_(2K) with similar molecular weight,PPa-PEG_(2K) significantly increases the stability,prolongs the systemic circulation and improves the tumor-homing ability and ROS generation efficiency of PPa-nanoassembly.As a result,PPa/PPa-PEG_(2K) NPs exert potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model.Together,such a core-matched nanoassembly of pure photosensitizer provides a new strategy for the development of imaging-guided theragnostic nanomedicines. 关键词：Pure drug-assembled nanomedicines Pure photosensitizer Pyropheophorbide a Core-matched Self-assembly Nanoassembly Imaging-guided Photodynamic therapy

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Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy

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