维普中文期刊产品整合服务

Reappraise role of lymph node status in patterns of recurrence following curative resection of gastric adenocarcinoma

查看全文 作　　者：Yihui [1]Tang;Jianxian [1,2]Lin;Junpeng [1]Lin;Jiabin [1,2]Wang;Jun [1,2]Lu;Qiyue [1,2]Chen;Longlong [2]Caolj;Mi [1]Lin;Ruhong [1]Tu;Changming [1,2]Huang;Ping [1,2]Li;Chaohui [1,2]Zheng;Jianwei [1,2]Xie 高影响力作者 机构地区：[1]Department of Gastric Surgery,Fujian Medical University Union Hospital,Fuzhou 350001,China;[2]Key Laboratory of Ministry of Education of Gastrointestinal Cancer,Fujian Medical University,Fuzhou 350108,China高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2021年第33卷第3期,共12页高影响力期刊 基　　金：supported by Scientific and Technological Innovation Joint Capital Projects of Fujian Province, China (No. 2017Y9011);Minimally Invasive Medical Center of Fujian Province (No. [2017]171);Project supported by the Science Foundation of the Fujian Province, China (No. 2018J01307);Joint Funds for the innovation of science and Technology, Fujian province (No. 2018Y9041)。 摘　　要：Objective: To examine the association between lymph node status and recurrence patterns in completely resected gastric adenocarcinoma.Methods: We retrospectively assessed 1,694 patients who underwent curative gastrectomy from January 2010 to August 2014. Patients stratified according to lymph node status and recurrence patterns among different subgroups were compared.Results: Of all, 517(30.5%) patients developed recurrent disease, and complete data of recurrence could be obtained in 493(95.4%) patients. For p^(N0) patients, the patterns of recurrence were different according to p T stage: locoregional recurrence was most common in patients with p T1-2 disease(57.1%), distant recurrence was most common in patients with p T3 disease(57.1%), and peritoneal recurrence was most common in patients with p T4 a disease(66.7%). For p^(N+) patients, distant metastasis was most common pattern irrespective of p T stage. The site-specific trend of recurrence showed that locoregional recurrence increased within 5 years in patients with p^(N0)-2 disease but plateaued 3 years after surgery in patients with p N3 disease. Time to recurrence was significantly longer for the p^(N0) patients compared with the p^(N+) patients(median: 25 vs. 16 months, P=0.001).Moreover, post-recurrence survival was significantly better for the p^(N0) patients than for the p^(N+) patients(median:12 vs. 6 months, P<0.001), especially in patients with non-peritoneal recurrence, late recurrence, single recurrence,and receipt of potential curative treatment.Conclusions: Among clinicopathologic factors, lymph node status is the most important factor associated with recurrence patterns after curative gastrectomy. Lymph node status may be used as an adjunct in clinical decisionmaking about postoperative therapeutic and follow-up strategies. 关 键 词：Recurrence patterns lymph node status post-recurrence survival recurrence-free survival gastric cancer
相关文献

参考文献(29)

引证文献(1)

耦合文献(137)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费