Prognostic impact of gene copy number instability and tumor mutation burden in patients with resectable gastric cancer

查看全文 作　　者：Lisheng [1]Cai;Linhai [2]Li;Dandan [3]Ren;Xue [3]Song;Beibei [3]Mao;Bo [4]Han;Henghui [5]Zhang

机构地区：[1]Department of General Surgery,Zhangzhou Afiliated Hospital of Fujian Medical University,Zhangzhou,Fujian,363000,P.R.China;[2]Department of General Surgery,The First People's Hospital of Yunnan Province,The Affliated Hospital of Kunming University of Science and Technology,Kunming,Yunan,650032,P.R.China;[3]Genecast Precision Medicine Technology Institute,Beijing,100191,P.R.China;[4]The Second Ward of Oncology Department,The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongiang,150086,P.R.China;[5]Institute of Infectious Diseases,Bejing Ditan Hospital,Capital Medical University,Beijing,100015,P.R.China

出　　处：《Cancer Communications》索引2020年第40卷第1期,共4页

基　　金：This work was supported by grant from the National Key Sci-Tech Special Project of China[No.2018ZX 10302207]. 摘　　要：Dear Editor,Gastric cancer(GC)is a leading cause of cancer-related deaths worldwide,especially in China and other East Asian countries[1,2].Although considerable achievements have been made in its treatment[3]and predictive biomarkers[4]in past decades,the prognosis of GC remains poor[5].Therefore,more effective prognostic markers are needed to improve the prognosis prediction of GCs.Small panels based on next-generation sequencing,such as FoundationOne CDx and MSK-IMPACT,are widely used for selecting appropriate treatment approaches(such as targeted therapies,immunotherapies,and chemotherapies)with the advantages of a higher sequencing depth and more cost-effectiveness than whole-exome sequencing(WES).Previous studies have demonstrated that molecular characteristics based on the designed cancer-related gene panel were consistent with those determined by WES and could be prognostic markers for various cancer types[6-8].As such,we analyzed the molecular features with the designed panel to investigate probable prognostic biomarkers for Chinese patients with GC. 关键词：PATIENTS GASTRIC treatment

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Prognostic impact of gene copy number instability and tumor mutation burden in patients with resectable gastric cancer

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