The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1

查看全文 作　　者：Xuedan [1]Guo;Zhi [2]Wang;Qing [1]Sun;Chunhua [1]Sun;Hongxia [1]Hua;Qing [3]Huang

机构地区：[1]Department of Oncology,Wuxi No.2 People’s Hospital Affiliated to Nanjing Medical University,Wuxi 214002,China;[2]Department of Rehabilitation,Wuxi Tongren Rehabilitation Hospital,Wuxi 214151,China;[3]Department of Emergency,Wuxi People’s Hospital Affiliated to Nanjing Medical University,Wuxi 214023,China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2020年第52卷第10期,共8页

基　　金：This work was supported by the grant from the Project of Wuxi Municipal Science and Technology Bureau(No.CSE31N1621). 摘　　要：Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer(NSCLC),and microRNA-1827(miR-1827)is closely correlated with NSCLC metastasis.In this study,we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC.The results showed that miR-1827 level was decreased in tumor tissues and cells and was correlated with tumor grade and lymph node(LN)metastasis.Overexpression of miR-1827 inhibited anchorage-independent growth and anoikis resistance in A549 cells.Bioinformatics and functional analysis identified that caveolin-1(CAV-1)is directly targeted by miR-1827.Restoration of CAV-1 significantly attenuated miR-1827’s effect on anoikis resistance in A549 cells.Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance,which might serve as a potential therapeutic target for metastatic NSCLC. 关键词：NSCLC anoikis resistance microRNA-1827 CAVEOLIN-1 A549 cell

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The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1

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