Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

查看全文 作　　者：Yajing [1,2]Fu;Yuanxiong [3]Cheng;Yuntao [4]Wu

机构地区：[1]NHC Key Laboratory of AIDS Immunology(China Medical University),Department of Laboratory Medicine,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;[2]National Clinical Research Center for Laboratory Medicine,The First Affiliated Hospital of China Medical University,Shenyang 110001,China;[3]Department of Respiratory and Critical Care Medicine,The Third Affiliated Hospital of Southern Medical University,Guangzhou 510275,China;[4]National Center for Biodefense and Infectious Diseases,School of Systems Biology,George Mason University,Manassas,VA 20110,USA

出　　处：《Virologica Sinica》索引2020年第35卷第3期,共6页

摘　　要：Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness. 关键词：SARS-CoV-2 Inflammatory response Fc receptors(FcR) Antibody-dependent enhancement(ADE)

相关文献

参考文献（37）
引证文献（65）
耦合文献（0）

参考文献(37)

引证文献(65)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

参考文献(37)

引证文献(65)

用户提示