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Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

查看全文 作　　者：Mi Hyeon [1]Cho;Yan [1]Li;Pui‑Chi [2]Lo;Hyeri [1]Lee;Yongdoo [1]Choi 高影响力作者 机构地区：[1]Division of Translational Science,Research Institute,National Cancer Center,323 Ilsan‑ro,Goyang,Gyeonggi 10408,Republic of Korea;[2]Department of Biomedical Sciences,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong,China高影响力机构 出　　处：《Nano-Micro Letters》索引2020年第12卷第4期,共15页高影响力期刊 基　　金：supported by the Ministry of Oceans and Fisheries,Korea(the project title:Development of marine material based near infrared fluorophore complex and diagnostic imaging instruments);by a Grant(1910070)from the National Cancer Center 摘　　要：In this study, a fucoidan-based theranostic nanogel(CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve acti-vatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy(PDT) to induce the com-plete death of cancer cells. A CFN-gel has nanomolar a nity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention e ect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar a nity for the vascular endothelial growth factor, it also provides a significant anti-tumor e ect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high e cacy and specificity. 关 键 词：FUCOIDAN Theranostic nanogel P-SELECTIN Activatable ANTI-ANGIOGENIC
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