Metallothionein expression in hepatocellular carcinoma

查看全文 作　　者：Geng-Wen Huang Lian-Yue Yang Department of General Surgery,Xiangya Hospital,Central South University,Changsha 410008,Hunan Province,China

出　　处：《World Journal of Gastroenterology》索引2002年第8卷第4期,共4页

基　　金：the Science Fund of Department of Science and Technology of Hunan Province,No.98ssy1008 摘　　要：AIM: To investigate the expression of metallothioneins(MTs), which were recently thought to have closerelationship with tumors, in human hepatocellularcarcinoma.METHODS: Histological specimens of 35 cases of primaryhuman hepatocellular carcinoma with para-neoplasticliver tissue and 5 cases of normal liver were stainedfor MTs with monoclonal mouse anti-MTs serum (Eg)by the immunohistochemical ABC technique. RESULTS: MTs were stained in the 35 cases of HCC,including 6 cases negative (17.1 %), 23 weaklypositive (65.7 %), and 6 strongly positive(17.1%).But MTs were stained strongly positive in all the fivecases of normal liver and 35 cases of para-neoplasticliver tissue. The differences of MTs expression betweenHCC and normal liver tissue or para-neoplastic livertissue were highly significant (P<0.01). The rate ofMTs expression in HCC grade I was 100 percent,higher than that in grade Ⅱ(81%) and grade Ⅲand Ⅳ (78 %). But the differences were notsignificant (P>0.05). No obvious correlationsbetween MTs expression in HCC and tumor size,clinical stage or serum alpha fetoproteinconcentration were found (P>0.05).CONCLUSION: Decrease of MTs expression in HCC mayplay a role in carcinogenesis of HCC. MTs are stainedheterogenously in HCC. We can choose the anticanceragents according to the MTs concentraiton in HCC, whichmay improve the results of chemotherapy for HCC. 关键词：肝癌金属硫蛋白蛋白表达临床意义免疫组织化学ABC法

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Metallothionein expression in hepatocellular carcinoma

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