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Di(2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats

查看全文 作　　者：ZHANG Yue [1]Zhu;ZHANG Zhao [1]Ming;ZHOU Li [1]Ting;ZHU [1]Jian;ZHANG Xiao [1]Han;QI [1]Wen;DING [1]Shuang;XU [1]Qi;HAN [1]Xu;ZHAO Ya [1]Ming;SONG Xin [1]Yue;ZHAO Tian [1]Yang;YE [1]Lin 高影响力作者 机构地区：[1]Department of Occupational and Environmental Health, School of Public Health, Jilin University高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2019年第32卷第6期,共13页高影响力期刊 基　　金：supported by grants from the National Natural Science Foundation of China [Grant No.81573184] 摘　　要：Objective Previous studies have indicated that the plasticizer di(2-ethylhexyl) phthalate(DEHP) affects lipid accumulation;however, its underlying mechanism remains unclear. We aim to clarify the effect of DEHP on lipid metabolism and the role of TYK2/STAT1 and autophagy. Methods In total, 160 Wistar rats were exposed to DEHP [0, 5, 50, 500 mg/(kg·d)] for 8 weeks. Lipid levels, as well as mRNA and protein levels of TYK2, STAT1, PPARγ, AOX, FAS, LPL, and LC3 were detected. Results The results indicate that DEHP exposure may lead to increased weight gain and altered serum lipids. We observed that DEHP exposure affected liver parenchyma and increased the volume or number of fat cells. In adipose tissue, decreased TYK2 and STAT1 promoted the expression of PPARγ and FAS. The mRNA and protein expression of LC3 in 50 and 500 mg/(kg·d) groups was increased significantly. In the liver, TYK2 and STAT1 increased compensatorily;however, the expression of FAS and AOX increased, while LPL expression decreased. Joint exposure to both a high-fat diet and DEHP led to complete disorder of lipid metabolism. Conclusion It is suggested that DEHP induces lipid metabolism disorder by regulating TYK2/STAT1. Autophagy may play a potential role in this process as well. High-fat diet, in combination with DEHP exposure, may jointly have an effect on lipid metabolism disorder. 关 键 词：DEHP TYK2 STAT1 HIGH-FAT diet AUTOPHAGY Lipid metabolism
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