Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival

查看全文 作　　者：Puneet [1]Gandhi;Richa [1]Khare;Nitin [2,3]Garg;Sandeep [2]Sorte

机构地区：[1]Department of Research, Bhopal Memorial Hospital and Research Centre;[2]Department of Neurosurgery, Bhopal Memorial Hospital and Research Centre;[3]Bansal Hospital

出　　处：《World Journal of Clinical Cases》索引2017年第5卷第6期,共7页

基　　金：Supported by M.P.Biotech Council,M.P.for financial assistance and BMHRC for infrastructural facilities,No.249 摘　　要：Glioblastoma-multiforme(GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival(PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-yearold patient who presented with progressive slurring of speech and features of raised intracranial pressure. Computed tomography(CT) scan revealed a large heterogeneously enhancing lesion in the left front-temporalperisylvian region with solid, cystic areas, suggestive of malignant glioma. Partial tumor-excision was followed by concurrent chemo-radiotherapy. Histopathologically, the tumor was astrocytoma grade-IV. Patient had an extended PFS of 12 mo, with an overall survival of 26 mo. Primary-GBM was confirmed using molecular markers and the immunophenotypic signature was defined by evaluating systemic expression of human telomerase reverse transcriptase, interleukin-6, neutrophil-lymphocyte ratio, tissue inhibitor of metalloproteinases-1, human chitinase-3-like-protein-1(YKL-40) and high mobility group-A1. Current findings suggest that this signature can identify worst outcomes, independent of clinical criteria. 关键词：GLIOBLASTOMA MULTIFORME Immunophenotypic SIGNATURE Progression free survival Molecular markers Human TELOMERASE reverse transcriptase INTERLEUKIN-6 Tissue inhibitor of metalloproteinases-1 YKL-40 High mobility group-A1

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Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival

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