Inhibition effects of perfluoroalkyl acids on progesterone production in mLTC-1

查看全文 作　　者：Wei [1]Zhao;Ruina [1]Cui;Jianshe [1]Wang;Jiayin [1]Dai

机构地区：[1]Key Laboratory of Animal Ecology and Conservation Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Journal of Environmental Sciences》索引2017年第29卷第6期,共9页

基　　金：supported by the National Basic Research Program(973)of China(No.2013CB945004) 摘　　要：Perfluoroalkyl substances(PFASs) are a class of fluorine substituted carboxylic acid, sulfonic acid and alcohol, structurally similar to their corresponding parent compounds. Previous study demonstrated the potential endocrine disruption and reproductive toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid, two dominant PFASs in animals and humans. We explored the relationship between eleven perfluoroalkyl acids(PFAAs)with different carbon chain length and their ability to inhibit progesterone production in mouse Leydig tumor cells(m LTC-1). We found an obvious dose–response relationship between progesterone inhibition rate and PFAA exposure concentration in m LTC-1. The relative inhibition rate of progesterone by PFAAs was linearly related to the carbon chain length and molar refractivity of PFAAs. Mitochondrial membrane potential(MMP) decreased after PFAA exposure at the half-maximal inhibitory effect concentration(IC_(50)) of progesterone production in m LTC-1, while the reactive oxygen species(ROS) content increased significantly. These results imply that the inhibition effect of PFAAs on progesterone production might be due, in part, to ROS damage and the decrease in MMP in m LTC-1. 关键词：内分泌干扰细胞分泌抑制作用全氟烷基孕酮剂量-反应关系全氟化合物相对抑制率

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Inhibition effects of perfluoroalkyl acids on progesterone production in mLTC-1

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