PIM2 regulates stemness through phosphorylation of 4E-BP1

查看全文 作　　者：Hongyan [1,2]Sun;Jiani [1]Cao;Lin [1,3]Zhao;Shaohua [1]Zhu;Shenghui [1,2]Chen;Yaqiong [1,2]Li;Bin [4]Zhao;Tongbiao [1,2]Zhao

机构地区：[1]astate Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;[2]Graduate University of Chinese Academy of Sciences, Beijing 100049, China;[3]Chinese Medicine Hospital in Linyi City, Linyi 276600, China;[4]Life Sciences Institute, Zhejiang University, Hangzhou 310058, China

出　　处：《Science Bulletin》索引2017年第62卷第10期,共7页

基　　金：supported by the National Basic Research Program of China (2013CB966901);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01040108);The National Thousand of Talents Program to T.Z., and the National Natural Science Foundation of China (31570995, 31621004) to T.Z. and (31400831) to J.C. 摘　　要：Embryonic stem cells(ESCs) can undergo unlimited self-renewal and maintain pluripotency to differentiate into any cell type of the three germ layers. Extensive studies have shown ESC identity is regulated by transcription factors, epigenetic regulators and multiple signal transduction pathways. However, the kinase regulation of pluripotency is not well understood. Here we show that the serine/threonine kinase PIM2, which is highly expressed in ESCs but not in somatic cells, functions as a crucial stemness regulator in ESCs. Knockout of Pim2 inhibits the self-renewal and differentiation capability of ESCs. Mechanistic studies identified that PIM2 can directly phosphorylate 4E-BP1, leading to release of e IF4E which facilitates the translation of pluripotent genes in ESCs. Our study highlights a novel kinase cascade pathway for ESC identity maintenance. 关键词：胚胎干细胞磷酸化蛋白丝氨酸/苏氨酸激酶 ESCS 信号转导通路自我更新遗传调控 EIF4E

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PIM2 regulates stemness through phosphorylation of 4E-BP1

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