Identification of a Newly Isolated Getah Virus in the China-Laos Border,China

查看全文 作　　者：LI Yuan [1,2,3]Yuan;FU Shi [2,3]Hong;GUO Xiao [4]Fang;LEI Wen [2,3]Wen;LI Xiao [2,3]Long;SONG Jing [2,3]Dong;CAO [2,3]Lei;GAO Xiao [2,3]Yan;LYU [2,3]Zhi;HE [2,3]Ying;WANG Huan [2,3]Yu;REN Xiao [1,2,3]Jie;ZHOU Hong [4]Ning;WANG Gui [1]Qin;LIANG Guo [2,3]Dong

机构地区：[1]Shanxi Medical University,Taiyuan 030001,Shanxi,China;[2]State Key Laboratory of Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;[3]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Hangzhou 310058,Zhejiang,China;[4]Yunnan Institute of Parasitic Diseases,Pu'er 665000,Yunnan,China

出　　处：《Biomedical and Environmental Sciences》索引2017年第30卷第3期,共5页

基　　金：supported by grants from National Natural Science Foundation of China(81290342 and 81501757);Development Grant of State Key Laboratory of Infectious Disease Prevention and Control(2014SKLID103);the Special National Project on Research and Development of Key Biosafety Technologies(2016YFC1201900),China 摘　　要：In this study, we isolated a virus strain(YN12031) from specimens of Armigeres subalbatus collected in the China-Laos border. BHK-21 cells infected with YN12031 exhibited an evident cytopathic effect(CPE) 32 h post-infection. The virus particles were spherical, 70 nm in diameter, and enveloped; they also featured surface fibers. Molecular genetic analysis revealed that YN12031 was closely related to alpha viruses such as Chikungunya virus and Sindbis virus, and located in the same clade as MM2021, the prototype of Getahvirus(GETV) isolated in Malaysia in 1955. Phylogenetic analysis of the E2 and capsid genes further revealed that YN12031 was located in the same clade as the Russian isolate LEIV/16275/Mag. Analysis of the homology of nucleotides and amino acids in the coding area and E2 gene demonstrated that the YN12031 isolated from the China-Laos border(tropical region) was related closest to the LEIV/16275/Mag isolate obtained in Russia(North frigid zone area) among other isolates studied. These results suggest that GETV can adapt to different geographical environments to propagate and evolve. Thus, strengthening the detection and monitoring of GETV and its related diseases is very crucial. 关键词：Getah 病毒中国老挝边阶 Phenotypic 特征分子的进化

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Identification of a Newly Isolated Getah Virus in the China-Laos Border,China

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