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Cell transplantation for the treatment of spinal cord injury–bone marrow stromal cells and choroid plexus epithelial cells

查看全文 作　　者：Chizuka [1]Ide;Norihiko [1]Nakano;Kenji [1]Kanekiyo 高影响力作者 机构地区：[1]Central Research Laboratory,Aino University School of Health Science高影响力机构 出　　处：《Neural Regeneration Research》索引2016年第11卷第9期,共4页高影响力期刊 基　　金：supported in part by grants from the Japanese Ministry of Education,Culture,Sports,Science,and Technology(No.2300125 to CI,No.15K10957 to NN,and No.26870744 to KK) 摘　　要：Transplantation of bone marrow stromal cells(BMSCs) enhanced the outgrowth of regenerating axons and promoted locomotor improvements of rats with spinal cord injury(SCI).BMSCs did not survive long-term,disappearing from the spinal cord within 2–3 weeks after transplantation.Astrocyte-devoid areas,in which no astrocytes or oligodendrocytes were found,formed at the epicenter of the lesion.It was remarkable that numerous regenerating axons extended through such astrocyte-devoid areas.Regenerating axons were associated with Schwann cells embedded in extracellular matrices.Transplantation of choroid plexus epithelial cells(CPECs) also enhanced axonal regeneration and locomotor improvements in rats with SCI.Although CPECs disappeared from the spinal cord shortly after transplantation,an extensive outgrowth of regenerating axons occurred through astrocyte-devoid areas,as in the case of BMSC transplantation.These findings suggest that BMSCs and CPECs secret neurotrophic factors that promote tissue repair of the spinal cord,including axonal regeneration and reduced cavity formation.This means that transplantation of BMSCs and CPECs promotes 'intrinsic' ability of the spinal cord to regenerate.The treatment to stimulate the intrinsic regeneration ability of the spinal cord is the safest method of clinical application for SCI.It should be emphasized that the generally anticipated long-term survival,proliferation and differentiation of transplanted cells are not necessarily desirable from the clinical point of view of safety. 关 键 词：bone marrow stromal cell choroid plexus epithelial cell spinal cord injury axonal regeneration locomotor improvement intrinsic regeneration ability
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