Bio-Adaption between Magnesium Alloy Stent and the Blood Vessel:A Review

查看全文 作　　者：Jun [1,2]MaNan [1,2]ZhaoLexxus [1,2]BettsDonghui [1,2]Zhu

机构地区：[1]Department of Chemical,Biological and Bioengineering,North Carolina Agricultural and Technical State University,Greensboro,NC,USA;[2]NSF Engineering Research Center-Revolutionizing Metallic Biomaterials,North Carolina Agricultural and Technical State University,Greensboro,NC USA

出　　处：《Journal of Materials Science & Technology》索引2016年第32卷第9期,共12页

摘　　要：Biodegradable magnesium(Mg) alloy stents are the most promising next generation of bio-absorbable stents. In this article, we summarized the progresses on the in vitro studies, animal testing and clinical trials of biodegradable Mg alloy stents in the past decades. These exciting findings led us to propose the importance of the concept 'bio-adaption' between the Mg alloy stent and the local tissue microenvironment after implantation. The healing responses of stented blood vessel can be generally described in three overlapping phases: inflammation, granulation and remodeling. The ideal bio-adaption of the Mg alloy stent, once implanted into the blood vessel, needs to be a reasonable function of the time and the space/dimension. First, a very slow degeneration of mechanical support is expected in the initial four months in order to provide sufficient mechanical support to the injured vessels. Although it is still arguable whether full mechanical support in stented lesions is mandatory during the first four months after implantation, it would certainly be a safety design parameter and a benchmark for regulatory evaluations based on the fact that there is insufficient human in vivo data available, especially the vessel wall mechanical properties during the healing/remodeling phase. Second, once the Mg alloy stent being degraded, the void space will be filled by the regenerated blood vessel tissues. The degradation of the Mg alloy stent should be 100% completed with no residues, and the degradation products(e.g., ions and hydrogen) will be helpful for the tissue reconstruction of the blood vessel. Toward this target, some future research perspectives are also discussed. 关键词：生物适应性镁合金血管壁支架可生物降解机械性能综述局部组织

相关文献

参考文献（150）
引证文献（14）
耦合文献（0）

参考文献(150)

引证文献(14)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Bio-Adaption between Magnesium Alloy Stent and the Blood Vessel:A Review

参考文献(150)

引证文献(14)

用户提示