Biosynthesis-based artificial evolution of microbial natural products

查看全文 作　　者：Zhi [1]Lin;Dandan [2]Chen;Wen [1,2]Liu

机构地区：[1]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;[2]Huzhou Center of Bio-Synthetic Innovation, Huzhou 313000, China

出　　处：《Science China Chemistry》索引2016年第59卷第9期,共13页

基　　金：supported by the National Natural Science Foundation of China (81402831, 21520102004, 31430005, 21472231);Science and Technology Commission of Shanghai Municipality (Shanghai, China) (14JC1407700, 15JC1400400) of China 摘　　要：Natural products are often secondary metabolites in living organisms with a wide variety of biological activities. The diversification of their structures, aiming to the search for biologically active small molecules by expanding chemical and functional spaces, is a major area of current interest in synthetic chemistry. However, developing synthetic accessibility and efficiency often faces challenges associated with structural complexity. Synthetic biology has recently emerged and is promising to accomplish complex molecules; by contrast, the application to structural diversification of natural products relies on the understanding, development and utilization of compatible biosynthetic machinery. Here, we review the strategies primarily concerning the artificial evolution of microbial natural products whose biosynthesis features template enzymology,including ribosomally synthesized and post-translationally modified peptides as well as the assembly line-resultant polyketides,non-ribosomal peptides and hybrids. The establishment of these approaches largely facilitates the expansion of the molecular diversity and utility through bioengineering at different stages/levels of biosynthetic pathways. 关键词：微生物天然产物生物合成途径人工进化次生代谢产物聚酮类化合物生物活性化学领域合成生物学

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Biosynthesis-based artificial evolution of microbial natural products

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