Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances

查看全文 作　　者：Bruno [1]Gallinella;Rosella [1]Ferretti;Leo [1]Zanitti;Isabella [1]Sestili;Antonina [1]Mosca;Roberto [1]Cirilli

机构地区：[1]Istituto Superiore di Sanita, Dipartimento del Farmaco, Viale Regina Elena 299, 1-00161 Rome, Italy

出　　处：《Journal of Pharmaceutical Analysis》索引2016年第6卷第2期,共5页

摘　　要：A simple analytical high-performance liquid chromatography(HPLC) method was applied for the enantiomeric excess determination of esomeprazole((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase(CSP)under reversed-phase conditions. The results were evaluated and compared with those obtained by the of fi cial enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of(S)-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of(S)-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor speci fi city due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity(R)-OME(impurity F). 关键词：反相高效液相色谱法对映体过量纯度测定相关物质奥美拉唑手性固定相有机杂质光学纯度

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Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances

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