Recent progress in the discovery of inhibitors targeting coronavirus proteases

查看全文 作　　者：Haofeng [1]Wang;Song [1]Xue;Haitao [1]Yang;Cheng [1]Chen

机构地区：[1]School of Life Sciences, Tianjin University

出　　处：《Virologica Sinica》索引2016年第31卷第1期,共7页

基　　金：supported by the Tianjin University Undergraduate Research Foundation;Tianjin University-Hainan University Collaborative Foundation;National Natural Science Foundation of China (No.31300150);Tianjin Marine Science and Technology Program (No.KJXH2014-16) 摘　　要：Coronaviruses(CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases(M^(pro)s), which could help develop effective treatments to prevent CoV infection. 关键词：病毒学临床医学药物学

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Recent progress in the discovery of inhibitors targeting coronavirus proteases

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