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Effect of depot medroxyprogesterone acetate(DMPA) on bone mineral density(BMD) and evaluating changes in BMD after discontinuation of DMPA in adolescent women

查看全文 作　　者：Cheng-wu [1]SHEN;Ling [2]GAI;Li-hong [2]ZHANG;Lin-lin [2]WANG;Hai-qing [2]DING;Hui [3]JIANG 高影响力作者 机构地区：[1]Shandong Provincial Hospital Affiliated to Shandong University;[2]Key Laboratory for Improving Birth Outcome Technique, Shandong Provincial Institute of Science and Technology for Family Planning;[3]The Family Planning Committee of Tao Luo Town in International Ocean City of Rizhao高影响力机构 出　　处：《Journal of Reproduction and Contraception》索引2015年第26卷第3期,共9页高影响力期刊 基　　金：supported by a grant from the Research Foundation of the Shandong Provincial Population and Committee of Family Planning,Jinan,Shandong,China(No.2012017) 摘　　要：Objective To compare bone mineral density(BMD) between users of intramuscular depot medroxyprogesterone acetate(DMPA) and nonhormonal subjects and evaluated the changes in BMD after discontinuation of DMPA.Methods The study included 102 women aged 16-18 years using DMPA for 24 months and 97 same-age nonusers. BMD of the lumbar spine and femoral neck were measured using dual-energy X-ray absorptiometry. The mean BMD values were compared between DMPA users(DMPA group) and nonusers(control group) and the changes of BMD during 36 months after discontinuation of DMPA were observed.Results Mean BMD at the spine and femoral neck did not differ significantly between DMPA group and control group over 12 months, but the BMD values at both anatomical sites were significantly lower in DMPA group than in control group after 24 months treatment. After DMPA discontinuation, the mean BMD values in DMPA users increased substantially. At 24 months after DMPA discontinuation, there were no significant differences between DMPA group and control group. But the values of the lumbar spine and femoral neck BMD in DMPA group were still 1.70% and 1.87%, respectively,below nonusers at 36 months after DMPA discontinuation.Conclusion The use of DMPA for short-term(≤12 months) had no significant effects on BMD at spine and femoral neck, but long-term exposure to DMPA had significantloss in BMD in adolescents. Bone loss occurring with DMPA use is reversible after DMPA discontinuation. 关 键 词：DMPA BMD 骨密度 甲孕酮 物质密度 评价 醋酸 青少年
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