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Penile erectile dysfunction after brachial plexus root avulsion injury in rats

查看全文 作　　者：Guo [1]Fu;Bengang [1]Qin;Li [2]Jiang;Xijun [3]Huang;Qinsen [4]Lu;Dechun [5]Zhang;Xiaolin [1]Liu;Jiakai [1]Zhu;Jianwen [1]Zheng;Xuejia [6]Li;Liqiang [1]Gu 高影响力作者 机构地区：[1]Department of Orthopedic Trauma & Microsurgery,the First Affiliated Hospital of Sun Yat-sen University;[2]Orthopedic Institute,Eastern Hospital,the First Affiliated Hospital of Sun Yat-sen University;[3]Department of Upper Limb Orthopedics,Eastern Hospital,the First Affiliated Hospital of Sun Yat-sen University;[4]Emergency Department,Shandong Provincial Hospital;[5]Department of Orthopedics,the Affiliated Hospital of Binzhou Medical College;[6]Office of Research Service,the First Affiliated Hospital of Sun Yat-sen University高影响力机构 出　　处：《Neural Regeneration Research》索引2014年第9卷第20期,共5页高影响力期刊 基　　金：supported by the National Key Clinical Specialist Construction Programs of China,No.201402016;the Science and Technology Planning Project of Guangdong Province,China,No.2011A032100001 摘　　要：Our previous studies have demonstrated that some male patients suffering from brachial plexus injury,particularly brachial plexus root avulsion,show erectile dysfunction to varying degrees.However,the underlying mechanism remains poorly understood.In this study,we evaluated the erectile function after establishing brachial plexus root avulsion models with or without spinal cord injury in rats.After these models were established,we administered apomorphine(via a subcutaneous injection in the neck) to observe changes in erectile function.Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation.Expression of neuronal nitric oxide synthase did not change in brachial plexus root avulsion rats.However,neuronal nitric oxide synthase expression was significantly decreased in brachial plexus root avulsion + spinal cord injury rats.These findings suggest that a decrease in neuronal nitric oxide synthase expression in the penis may play a role in erectile dysfunction caused by the combination of brachial plexus root avulsion and spinal cord injury. 关 键 词：勃起功能障碍 神经损伤 神经元型一氧化氮合酶 根性 阴茎 大鼠 脊髓损伤 皮下注射
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