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Resting state brain default network in patients with motor aphasia resulting from cerebral infarction

查看全文 作　　者：Xin [1]Wang;Meihao [1]Wang;Weizhuo [2]Wang;Huiru [1]Liu;Jiejie [1]Tao;Chuang [3]Yang;Jiance [1]Li 高影响力作者 机构地区：[1]Department of Radiology,First Affiliated Hospital of Wenzhou Medical University;[2]Department of Radiology,Nankai Hospital of Tianjin;[3]Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University高影响力机构 出　　处：《Chinese Science Bulletin》索引2014年第59卷第31期,共8页高影响力期刊 摘　　要：To explore the brain default mode network(DMN)in patients with motor aphasia resulting from cerebral infarction,we used resting state functional magnetic resonance imaging(fMRI)to investigate the possible neural mechanism.Thirteen patients with motor aphasia resulting from cerebral infarction and ten matched controls were selected in this study.All subjects were examined using resting state fMRI.We chose the posterior cingulate cortex as the region of interest and then used functional connectivity analysis to calculate the DMN functional connectivity and analyze differences in the functional connectivity between the two groups.Compared with normal controls,aphasia patient group showed a significantly decreased functional connectivity in bilateral medial frontal gyrus,superior frontal gyrus,middle frontal gyrus,middle temporal gyrus,precuneus and cuneus.The aphasia patient group showed increased functional connectivity mainly in bilateral medial frontal gyrus,middle frontal gyrus,inferior frontal gyrus,precentral gyrus,insula.The DMN in cerebral infarction motor aphasia patients showed significantly decreased functional connectivity in the resting state.The DMN most likely plays an important role in motor aphasia resulting from cerebral infarction.Furthermore,functional connectivity in the brain regions surrounding the left and right Broca’s areas was significantly enhanced due to compensatory mechanisms.This may be helpful for the recovery of language function in cerebral infarction patients with motor aphasia. 关 键 词：运动性 患者 大脑 状态 静息 网络 功能磁共振成像 显示功能
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