Aurora-A is a novel predictor of poor prognosis in patients with resected lung adenocarcinoma

查看全文 作　　者：Bo [1]Zeng;Yiyan [1]Lei;Haoshuai [1]Zhu;Shenyuan [1]Luo;Mei [2]Zhuang;Chunhua [1]Su;Jianyong [1]Zou;Lei [1]Yang;Honghe [1]Luo

机构地区：[1]Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University;[2]Private Medical Center, The First Affiliated Hospital, Sun Yat-sen University

出　　处：《Chinese Journal of Cancer Research》索引2014年第26卷第2期,共8页

基　　金：supported by grants from the Guangdong Provincial Science &Technology Project of China (no 2009B060700036);the Guangdong Provincial Nature Foundation for Doctor Initiative of China (no S2011040002465) 摘　　要：Background: The Aurora-A(Aur-A) gene, a key regulator of mitosis, has been proved as an oncogene in a variety of cancers. The Aur-A overexpression has been proved correlated with aggressiveness of cancer cells. However, the frequency of Aur-A protein overexpression, as well as its association with clinicopathologic parameters and prognosis remain unclear in lung adenocarcinoma(ADC). This study tried to clarify the clinical significance of Aur-A in patients with resected lung ADC. Patients and methods: A total of 142 informative patients with surgically resected lung ADC and 20 normal lung tissues were enrolled. Western blot and immunohistochemistry(IHC) were utilized to assess protein expression of Aur-A.Result: The expression of Aur-A was elevated in most of tumor tissues compared with the adjacent tissues by western blot. The IHC results showed that Aur-A protein was over-expressed in 98 of 142(69.0%) tumor sections, while Aur-A was low-expressed in all normal lung sections. A positive correlation between Aur-A overexpression rate and ascending pathologic stages was observed(P<0.05). Kaplan-Meier analysis demonstrated that patients with Aur-A high expression had significantly inferior survival compared to those with Aur-A low expression. Both overall survival(OS) and disease-free survival(DFS) of positive overexpression patients were shorter than the negative group(P=0.036, P=0.041, respectively). Multivariate analysis confirmed that Aur-A expression, as an independent and significant factor for both DFS and OS, could predict a poor prognosis in patients with resected lung ADC(P=0.022, P=0.049, respectively).Conclusions: Aur-A was overexpressed in lung ADC and overexpression of Aur-A might be a novel predictor for poor prognosis and potential therapeutic target in lung ADC. 关键词：手术切除肺腺癌患者预后预测极光过度表达免疫组织化学

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Aurora-A is a novel predictor of poor prognosis in patients with resected lung adenocarcinoma

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