Atorvastatin protects against cerebral ischemia/ reperfusion injury through anti-inflammatory and antioxidant effects

查看全文 作　　者：Qiuyun [1]Tu;Hui [2]Cao;Wei [2]Zhong;Binrong [1]Ding;Xiangqi [2]Tang

机构地区：[1]Department of Geriatrics, Third Xiangya Hospital of Central South University;[2]Department of Neurology, Second Xiangya Hospital of Central South University

出　　处：《Neural Regeneration Research》索引2014年第9卷第3期,共8页

基　　金：the Natural Science Foundation of Hunan Province in China,No.11JJ5081;grants from Hunan Provincial Science and Technology Department in China,No.2012SK3226 and 2011SK3236;the National Natural Science Foudation of China,No.81271298/H0906 摘　　要：In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/ reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and superoxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. 关键词：缺血再灌注损伤抗氧化作用大脑皮质抗炎超氧化物歧化酶活性髓过氧化物酶 E-选择素降脂作用

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Atorvastatin protects against cerebral ischemia/ reperfusion injury through anti-inflammatory and antioxidant effects

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引证文献(29)

耦合文献(520)

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