Gabapentin inhibits central sensitization during migraine

查看全文 作　　者：Yanbo [1,2]Zhang;Guo [3]Shao;Wei [4]Zhang;Sijie [1]Li;Jingzhong [2]Niu;Dongmei [2]Hu;Mingfeng [2]Yang;Xunming [1]Ji

机构地区：[1]Institute of Hypoxia Medicine,Xuanwu Hospital,Capital Medical University;[2]Department of Neurology,Affiliated Hospital of Taishan Medical University;[3]Biomedical Research Center,Baotou Medical College;[4]Department of Gastroenterology,Second Affiliated Hospital of Baotou Medical College

出　　处：《Neural Regeneration Research》索引2013年第8卷第32期,共10页

基　　金：financially sponsored by the Natural Science Foundation of Shandong Province,No.ZR2012HQ014;a grant from the Science and Technology Plan Program of Universities in Shandong Province,No.J10LF14 摘　　要：Peripheral and central sensitizations are phenomena that occur during migraine.The role of gabapentin,a migraine preventive drug,on central sensitization remains unclear.In this study,a rat model of migraine was established by electrical stimulation of the trigeminal ganglion,and the animals were given intragastric gabapentin.Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine.Electrophysiology,liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve,decreases excitatory amino acid content and inhibits the activation of protein kinase C.This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine.Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation. 关键词：加巴喷丁偏头痛中枢兴奋性氨基酸蛋白激酶C 三叉神经节氨基酸含量敏感

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Gabapentin inhibits central sensitization during migraine

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