Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction

查看全文 作　　者：Sijie [1]Li;Yanbo [2]Zhang;Guo [3]Shao;Mingfeng [2]Yang;Jingzhong [2]Niu;Guowei [1]Lv;Xunming [1]Ji

机构地区：[1]Institute of Hypoxic Medicine,Xuanwu Hospital, Capital Medical University;[2]Department of Neurology,Affiliated Hospital of Taishan Medical University;[3]Research Center of Biology and Medicine, Baotou Medical College

出　　处：《Neural Regeneration Research》索引2013年第8卷第31期,共9页

基　　金：supported by the National Natural Science Foundation of China,No.30870854;the Natural Science Foundation of Beijing,No.7111003;the Natural Science Foundation of Shandong Province,No.ZR2010HM029 摘　　要：Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction,but the mechanisms underlying this protection remain unclear.To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis,we induced a photochemical model of cerebral infarction in an inbred line of mice(BALB/c).Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment.Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction,mainly in neurons and vascular endothelial cells.Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31.Moreover,hypoxic preconditioning reduced the infarct volume and improved neurological function in mice.These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra,which promoted angiogenesis. 关键词：缺氧预适应血管生成脑梗塞缺血血管内皮生长因子急性血管内皮细胞近交系小鼠

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Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction

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