Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats

查看全文 作　　者：Qiuju [1,2]Yuan;Huanxing [3]Su;Kin [1]Chiu;Wutian [1,4,5,6]Wu;Zhi-Xiu [2]Lin

机构地区：[1]Department of Anatomy, The University of Hong Kong;[2]School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong;[3]State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macao;[4]State Key Laboratory of Brain and Cognitive Sciences,Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong;[5]Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong;[6]GHM Institute of CNS Regeneration, Jinan University

出　　处：《Neuroscience Bulletin》索引2013年第29卷第4期,共8页

基　　金：supported by the Hong Kong SCI Fund;the National Basic Research Development Program (973 program) of China (2011CB504402) 摘　　要：Conflicting findings exist regarding the link between functional recovery and the regrowth of spinal tracts across the lesion leading to the restoration of functional contacts. In the present study, we investigated whether functional locomotor recovery was attributable to anatomical regeneration at postnatal day 1 (PN1), PN7, PN14 and in adult rats two months after transection injury at the tenth thoracic segment of the spinal cord. The Basso, Beattie, and Bresnahan scores showed that transection led to a failure of hindlimb locomotor function in PN14 and adult rats. However, PN1 and PN7 rats showed a significant level of stepping function after complete spinal cord transection. Unexpectedly, unlike the transected PN14 and adult rats in which the spinal cord underwent limited secondary degeneration and showed a scar at the lesion site, the rats transected at PN1 and PN7 showed massive secondary degeneration both anterograde and retrograde, leaving a >5-mm gap between the two stumps. Furthermore, retrograde tracing with fluorogold (FG) also showed that FG did not cross the transection site in PN1 and PN7 rats as in PN14 and adult rats, and re-transection of the cord caused no apparent loss in locomotor performance in the rats transected at PN1. Thus, these three lines of evidence strongly indicated that the functional recovery after transection in neonatal rats is independent of regrowth of spinal tracts across the lesion site. Our results support the notion that the recovery of locomotor function in developing rats may be due to intrinsic adaptations in the spinal circuitry below the lesion that control hindlimb locomotor activity rather than the regrowth of spinal tracts across the lesion. The difference in secondary degeneration between neonatal and adult rats remains to be explored. 关键词：脊髓损伤成年大鼠功能恢复发展中国家病理学病变部位神经再生功能

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Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats

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