Biomaterials for spinal cord repair

查看全文 作　　者：Agnes E. [1,2]Haggerty;Martin [1,3,4,2]oudega

机构地区：[1]Departments of Bioengineering,University of Pittsburgh;[2]Departments of the Center for the Neural Basis of Cognition, University of Pittsburgh;[3]Departments of Physical Medicine and Rehabilitation,University of Pittsburgh;[4]Departments of Neurobiology,University of Pittsburgh

出　　处：《Neuroscience Bulletin》索引2013年第29卷第4期,共15页

基　　金：supported by the Wings for Life Foundation, Contract #: WFL-US-004/12 摘　　要：Spinal cord injury (SCi) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCi is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCi. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCi. A plethora of biomaterials is available and has been tested in various models of SCi. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi. 关键词：生物材料脊髓损伤修复中枢神经系统轴突再生 SCI 社会问题临床医生

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Biomaterials for spinal cord repair

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