Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease

查看全文 作　　者：Guang-Biao [1]Huang;Tong [1]Zhao;Sushma Shrestha [1]Muna;Hong-Mei [1]Jin;Jong-Il [1]Park;Kyu-Sik [2]Jo;Bo-Hee [2]Lee;Soo-Wan [3]Chae;Sun-Young [3]Kim;Soo-Hyun [3]Park;Eun-Ock [3]Park;Eun-Kyung [3]Choi;Young-Chul [1,4]Chung

机构地区：[1]Department of Psychiatry, Chonbuk National University Medical School,Jeonju 561-756, Republic of Korea;[2]Muju Chunma Native Local Industrial Center,Muju 568-844, Republic of Korea;[3]Clinical Trial Center for Functional Foods, Chonbuk National University Hospital,Jeonju 561-756, Republic of Korea;[4]Department of Pharmacology, Chonbuk National University Medical School,Jeonju 561-756, Republic of Korea

出　　处：《Neural Regeneration Research》索引2013年第8卷第12期,共10页

基　　金：funded by Muju Tianma Native Local Industrial Center,Korea 摘　　要：Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ 25-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer's disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume,while Ellman method showed significant decrease in the activity of acetylcholinesterase in all three regions (prefrontal cortex,medial septum and hippocampus). These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer's disease. 关键词：阿尔茨海默氏病治疗效果天麻 MORRIS水迷宫阿尔茨海默氏症胆碱乙酰转移酶淀粉样蛋白 BLOT分析

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Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease

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