An efficient synthesis of some new 3-bipyridinyl substituted coumarins as potent antimicrobial agents

查看全文 作　　者：Hemali [1]B.Lad;Rakesh [1]R.Giri;[1]D.I.Brahmbhatt

机构地区：[1]Department of Chemistry,Sardar Patel University

出　　处：《Chinese Chemical Letters》索引2013年第24卷第3期,共3页

基　　金：Finaneial assistance to HJP and RRG from the UGC 摘　　要：As a part of the ongoing studies in developing new antimicrobials,a series of structurally novel 3- bipyridinyl substituted coumarin derivatives 4a-f and 5a-f were synthesized by a single-step reaction protocol under Krohnke's reaction conditions.~1H NMR,^(13)C NMR,IR and mass spectral techniques were employed for the structural elucidation of the synthesized compounds.An evaluation of antimicrobial activity showed that almost all compounds exhibited better results than the referenced drugs.Among the synthesized derivatives 4f,5a and 5d were found to be the most potent analogs.Thus they could be promising lead for novel drugs. 关键词：香豆素衍生物高效合成联吡啶抗菌剂结构鉴定抗微生物剂反应合成反应条件

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An efficient synthesis of some new 3-bipyridinyl substituted coumarins as potent antimicrobial agents

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