Genetics of Nonalcoholic Fatty Liver Disease:An Overview

查看全文 作　　者：Jharna [1]Puppala;Siva Prasad [2]Siddapuram;Jyothy [1]Akka;Anjana [1]Munshi

机构地区：[1]Institute of Genetics and Hospital for Genetic Diseases,Osmania University,Begumpet;[2]Asian Institute of Gastroenterology,Somajiguda

出　　处：《Journal of Genetics and Genomics》索引2013年第40卷第1期,共8页

基　　金：supported by University Grants Commission, New Delhi,India 摘　　要：Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease in the world today.Its incidence in adults and children is rising rapidly due to the ongoing epidemics of obesity and type 2 diabetes.Hence,it has become a global public health issue.Environmental factors have been found to play a major role in the etiology of NAFLD,especially for genetically susceptible populations. Among these,one of the most important factors is junk food,especially the typical 'Western-style' diet rich in simple carbohydrates, saturated fat,and highly processed food materials.Genetic predisposition to NAFLD does occur;however,a precise definition of genetic factors responsible for NAFLD is still lacking.Specific variants of different genes have been shown to present a risk for NAFLD.Genetic studies might be helpful in the management of the disease by developing novel treatment strategies based on individual's genotype. 关键词：脂肪肝酒精性遗传学肝疾病 2型糖尿病碳水化合物遗传易感性肝脏疾病

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Genetics of Nonalcoholic Fatty Liver Disease:An Overview

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