Cryptococcus gattii infections in China: extent of the problem?

查看全文 作　　者：CHEN [1]Min;PAN Wei-[1]hua;Teun [2]Boekhout

机构地区：[1]Shanghai Key Laboratory of Molecular Medical Mycology,Department of Dermatology, Shanghai Changzheng Hospital,Second Military Medical University, Shanghai 200003, China;[2]CBS-KNAW Fungal Biodiversity Centre, Department of Yeast andBasidiomycete Research, 3584 CT, Utrecht, The Netherlands

出　　处：《Chinese Medical Journal》索引2013年第2期,共3页

基　　金：This study was supported by grants from the National Natural Science Foundation of China (No. 81201269) and National Basic Research Program of China (973 Program, No. 2013 CB531601). 摘　　要：Approximately 70 species are accepted in the genus Cryptococcus;1 however,only two species,Cryptococcus neoformans (C.neoformans,serotypes A,AD and D) and C.gattii (serotypes B and C) are responsible for almost all human cryptococcal infections,2,3 and resulted in over 1 million new cases of cryptococcosis in the world each year with over 600 000casualties.4 It is generally assumed that cryptococcal infections are acquired by inhalation of fungal spores,desiccated cells,or poorly encapsulated yeasts from environmental niches,such as decayed wood debris of certain tree species or bird droppings.5 Epidemiological surveys have shown that C neoformans caused about 80% of cryptococcosis cases globally each year,particularly in immunocompromised persons,such as human immunodeficiency virus (HIV)-infected people and acquired immunodeficiency syndrome (AIDS) patients,2,3 while C.gattii primarily infects apparently immunocompetent hosts,and is mainly responsible for the remaining cases of cryptococcosis.6。 关键词：新生隐球菌人类感染严重程度人类免疫缺陷病毒免疫功能低下中国真菌孢子流行病学

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Cryptococcus gattii infections in China: extent of the problem?

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