Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats

查看全文 作　　者：Jun [1]Wang;Yan [2]Cui;Jing [1]Ge;Meijing [3]Ma

机构地区：[1]Department of Gynaecology and Obstetrics, the 202 Hospital of People's Liberation Army, Shenyang 110003, Liaoning Province, China;[2]Department of Emergency Medicine, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China;[3]Department of Gynaecology and Obstetrics, the Second People's Hospital of Tongliao, Tongliao 280000, Inner Mongolia AutonomousRegion, China

出　　处：《Neural Regeneration Research》索引2012年第7卷第25期,共6页

基　　金：The Medical Science and Technology Foundation of Chinese PLA during Twelfth 'Five-year' Development Period(General Program),No. CWS11J003 摘　　要：Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly.To establish a hyperhomocysteinemic pregnant rat model,2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation.Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction.Results showed that systolic blood pressure,proteinuria/creatinine ratio,and plasma homocysteine levels in the hyperhomocys-teinemic pregnant rats increased significantly,and that body weight and brain weight of rat pups significantly decreased.Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups.These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups. 关键词：高同型半胱氨酸血症叶酸子痫症状大鼠模型注射给药大脑发育高半胱氨酸

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Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats

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