Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

查看全文 作　　者：Dong-Xing [1,2]Cao;Zhi-Jie [3]Li;Xiao-Ou [1]Jiang;Yick Liang [1]Lum;Ester [1]Khin;Nikki P [4]Lee;Guo-Hao [2]Wu;John M [3,4]Luk

机构地区：[1]Department of Pharmacology and Department of Surgery,National University Health System,Na-tional University of Singapore,Singapore 117597,Singapore;[2]Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China;[3]Department of Oncology,Roche R and D Center(China)Ltd.,Shanghai 201203,China;[4]Department of Surgery,The University ofHong Kong,Hong Kong,China

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第30期,共8页

摘　　要：Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. 关键词：治疗方案生物标志物骨桥蛋白肝癌胃癌恶性肿瘤靶标病理特点

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Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

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