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Five-year follow-up of 23 asymmetrical Parkinson's disease patients treated with unilateral subthalamic nucleus stimulation

查看全文 作　　者：Jinchuan [1]Liang;Xiaowu [1]Hu;Xiaoping [1]Zhou;Xiufeng [1]Jiang;Yiqun [1]Cao;Laixing [1]Wang;Aiguo [2]Jin;Jianmin [1]Liu 高影响力作者 机构地区：[1]Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China;[2]Department of Radiology, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China高影响力机构 出　　处：《Neural Regeneration Research》索引2012年第7卷第18期,共8页高影响力期刊 基　　金：supported by the foundation of Science and Technology Commission of Shanghai Municipality,No.101195400 摘　　要：In this study, 23 asymmetrical Parkinson's disease patients were treated with unilateral deep brain stimulation of the subthalamic nucleus and followed up for 5 years. At 5 years after stimulation treatment, Unified Parkinson's Disease Rating Scale II, III and axial symptom scores in the off-drug condition were significantly increased compared those at baseline. However, total Unified Parkinson's Disease Rating Scale II, III and axial symptom scores were significantly lower with stimulation-on compared with the synchronous stimulation-off state in off-drug condition, and the motor symptoms of contralateral side limbs were effectively controlled. Only low Hoehn-Yahr stage was correlated with good long-term postoperative improvement in motor symptoms. The mean levodopa-equivalent daily dose after stimulation treatment was significantly lower than that before treatment, but dyskinesias became worse. Our experimental findings indicate that unilateral deep brain stimulation of the subthalamic nucleus is an effective treatment for improving motor symptoms in well selected asymmetrical Parkinson's disease patients presenting no severe axial symptoms and dyskinesias. 关 键 词：帕金森氏病 不对称 治疗 丘脑 患者 单侧 随访 运动障碍
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