Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users

查看全文 作　　者：Wenfu [1]Hu;Xiangming [1,2]Fu;Ruobing [2]Qian;Xiangpin [2]Wei;Xuebing [3]Ji;Chaoshi [2]Niu

机构地区：[1]Department of Neurosurgery,Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui Province,China;[2]Department of Neurosurgery,Anhui Provincial Institute of StereotacUc Neurosurgery,Hefei 230001,Anhui Province,China;[3]Department of MRI,Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui Province,China

出　　处：《Neural Regeneration Research》索引2012年第7卷第18期,共6页

基　　金：sponsored by a grant from the National Natural Science Foundation of China,No.30973084-C160801,C010604;the Natural Science Foundation of Anhui Province,No.11040606M167 摘　　要：The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users. 关键词：海洛因前额叶使用者扣带回网络海马皮质功能磁共振成像

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Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users

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