Aspirin-induced small bowel injuries and the preventive effect of rebamipide

查看全文 作　　者：Kazuhiro [1]Mizukami;Kazunari [1]Murakami;Takashi [1]Abe;Kunimitsu [1]Inoue;Masahiro [1]Uchida;Tadayoshi [1]Okimoto;Masaaki [1]Kodama;Toshio [1]Fujioka

机构地区：[1]Department of General Medicine and Gastroenterology,Faculty of Medicine,Oita University

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第46期,共6页

基　　金：Supported by The Department of General Medicine and Gastroenterology,Oita University 摘　　要：AIM:To evaluate the influence of taking low-dose aspirin for 4 wk on small intestinal complications and to examine the preventive effect of rebamipide.METHODS:This study was conducted as a single-center,randomized,double-blind,cross-over,placebo-controlled study.Eleven healthy male subjects were enrolled.Each subject underwent video capsule endos-copy after 1 and 4 wk of taking aspirin and omepra-zole,along with either rebamipide or placebo therapy.The primary endpoint was to evaluate small bowel damage in healthy subjects before and after taking low-dose aspirin for 4 wk.RESULTS:The number of subjects with mucosal breaks(defined as multiple erosions and/or ulcers)were 1 at 1 wk and 1 at 4 wk on the jejunum,and 6 at 1 wk(P = 0.0061)and 7 at 4 wk on the ileum(P =0.0019).Rebamipide significantly prevented mucosal breaks on the ileum compared with the placebo group(P = 0.0173 at 1 wk and P = 0.0266 at 4 wk).CONCLUSION:Longer-term,low-dose aspirin adminis-tration induced damage in the small bowel.Rebamipide prevented this damage,and may be a candidate drug for treating aspirin-induced small bowel complications. 关键词：阿司匹林预防效果小肠损伤药物治疗低剂量并发症服用

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Aspirin-induced small bowel injuries and the preventive effect of rebamipide

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