Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis

查看全文 作　　者：Taro [1]Osada;Atsushi [2]Arakawa;Naoto [1]Sakamoto;Hiroya [2]Ueyama;Tomoyoshi [1]Shibuya;Tatsuo [1]Ogihara;Takashi [2]Yao;Sumio [1]Watanabe

机构地区：[1]Department of Gastroenterology,Juntendo University School of Medicine;[2]Department of Human Pathology,Juntendo University School of Medicine

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第46期,共7页

摘　　要：AIM:To validate the clinical relevance of autofluores-cence imaging(AFI)endoscopy for the assessment of inflammatory ulcerative colitis(UC).METHODS:A total of 572 endoscopic images were se-lected from 42 UC patients:286 taken with white light imaging(WLI)and 286 with AFI from the same sites.WLI images were assessed for overall mucosal inflammation according to Mayo endoscopic subscore(MES),and for seven characteristic endoscopic features.Likewise,AFI photographs were scored according to relative abundance of red,green and blue color com-ponents within each image based on an RGB additive color model.WLI and AFI endoscopic scores from the same sites were compared.Histological evaluation of biopsies was according to the Riley Index.RESULTS:Relative to red(r=0.52,P<0.01)or blue(r=0.56,P<0.01)color component,the green color component of AFI(r=-0.62,P<0.01)corresponded more closely with mucosal inflammation sites.There were signif icant differences in green color components between MES-0(0.396±0.043)and MES-1(0.340± 0.035)(P<0.01),and between MES-1 and ≥ MES-2(0.318±0.037)(P<0.01).The WLI scores for 'vascu-lar patterns'(r=-0.65,P<0.01),'edema'(r=-0.62,P<0.01),histology scores for 'polymorphonuclear cells in the lamina propria'(r=-0.51,P<0.01)and 'crypt architectural irregularities'(r=-0.51,P<0.01)showed correlation with the green color component of AFI.There were significant differences in green color components between limited(0.399± 0.042)and extensive(0.375±0.044)(P=0.014)polymorpho-nuclear cell inf iltration within MES-0.As the severity of the mucosal inflammation increased,the green color component of AFI decreased.The AFI green color com-ponent was well correlated with the characteristic en-doscopic and histological inflammatory features of UC.CONCLUSION:AFI has application in detecting inflammatory lesions,including microscopic activity in the co-lonic mucosa of UC patients,based on the green color component of images. 关键词：溃疡性结肠炎荧光成像炎症评估颜色分量 COM组件镜身自体

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Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis

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