Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus

查看全文 作　　者：Annalisa [1]Berzigotti;Marilena [2]Frigato;Elena [2]Manfredini;Lucia [1]Pierpaoli;Rita [2]Mulè;Carolina [1]Tiani;Paola [1]Zappoli;Donatella [1]Magalotti;Nazzarena [2]Malavolta;Marco [1]Zoli

机构地区：[1]Department of Internal Medicine Nephrology and Ageing University of Bologna,40138 Bologna Italy;[2]UOS Reumatologia Policlinico S Orsola-Malpighi,40138 Bologna Italy

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第40期,共6页

基　　金：Supported by Department of Internal Medicine,Nephrology and Ageing of University of Bologna,Italy 摘　　要：AIM:To investigate whether systemic lupus erythematosus (SLE) is associated with benign focal liver lesions and vascular liver diseases, since these have been occasionally reported in SLE patients. METHODS:Thirty-five consecutive adult patients with SLE and 35 age-and sex-matched healthy controls were evaluated. Hepatic and portal vein patency and presence of focal liver lesions were studied by colour-Doppler ultrasound, computerized tomography and magnetic resonance were used to refine the diagnosis, clinical data of SLE patients were reviewed. RESULTS:Benign hepatic lesions were common in SLE patients (54% vs 14% controls, P < 0.0001), withhemangioma being the most commonly observed lesion in the two groups. SLE was associated with the presence of single hemangioma [odds ratios (OR) 5.05; 95% confidence interval (CI) 1.91-13.38] and multiple hemangiomas (OR 4.13; 95% CI 1.03-16.55). Multiple hemangiomas were associated with a longer duration of SLE (9.9 ± 6.5 vs 5.5 ± 6.4 years; P = 0.04). Imaging prior to SLE onset was available in 9 patients with SLE and hemangioma, showing absence of lesions in 7/9. The clinical data of our patients suggest that SLE pos- sibly plays a role in the development of hemangioma. In addition, a Budd-Chiari syndrome associated with nodular regenerative hyperplasia (NRH), and a NRH associated with hepatic hemangioma were observed, both in patients hospitalized for abdominal symptoms, suggesting that vascular liver diseases should be specifically investigated in this population. CONCLUSION:SLE is associated with 5-fold increased odds of liver hemangiomas, suggesting that these might be considered among the hepatic manifestations of SLE. 关键词：系统性红斑狼疮血管疾病肝脏疾病患者计算机断层扫描 SLE 临床资料多普勒超声

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Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus

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