Reduction of Plasma MicroRNA-21 is Associated with Chemotherapeutic Response in Patients with Non-small Cell Lung Cancer

查看全文 作　　者：Juan Wei Lian-ke Liu Wen Gao Cheng-jun Zhu Yi-qian Liu Ting Cheng Yong-qian [1]Shu

机构地区：[1]Department of Oncology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China

出　　处：《Chinese Journal of Cancer Research》索引2011年第23卷第2期,共6页

基　　金：supported by the grants from the National Natural Science foundation of China (No. 30772549);the Development Foundation of Medical Science from Public Health Department of Jiangsu Province (No. P200965) 摘　　要：Objective: To examine plasma microRNA-21 (miR-21) level in patients with non-small cell lung cancer (NSCLC) and its potential correlation with chemotherapeutic response. Methods: 77 NSCLC patients and 36 age and sex-matched healthy controls were included. Plasma miR-21 concentration was examined using a quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR). Potential correlation between plasma mir-21 concentrations with chemotherapeutic responses was analyzed in 35 patients with advanced NSCLC (stages IIIB and IV). Results: Plasma miR-21 was significantly higher in NSCLC patients relative to the healthy controls (P<0.0001). As a biomarker, plasma mir-21 had a receiver operating characteristic (ROC) curve area of 0.729 with 61.04% sensitivity and 83.33% specificity. Chemotherapeutic response in the 35 patients with advanced NSCLC (stages IIIB and IV) included partial response (PR) (n=11), stable disease and progression disease (SD+PD) (n=24). The overall response rate (CR+PR) was 31.4%. Plasma miR-21 in patients who achieved PR was significantly lower than those who did not respond (SD+PD) (P=0.0487), and comparable to that of the healthy controls (P=0.2744). Conclusion: Plasma miR-21 is a good biomarker for NSCLC, and could be used to predict responses to chemotherapy. 关键词：非小细胞肺癌等离子体反应法化疗患者微RNA microRNA 血浆浓度

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Reduction of Plasma MicroRNA-21 is Associated with Chemotherapeutic Response in Patients with Non-small Cell Lung Cancer

参考文献(47)

引证文献(10)

耦合文献(1007)

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