Gastric ghrelin in relation to gender,stomach topography and Helicobacter pylori in dyspeptic patients

查看全文 作　　者：Krystyna Stec-[1]Michalska;Sebastian [2]Malicki;Blazej [3]Michalski;Lukasz [2]Peczek;Maria Wisniewska-[1]Jarosinska;Barbara [2]Nawrot

机构地区：[1]Department of Gastroenterology and Internal Diseases,Medical University of Lodz,Plac Hallera 1,90-647 Lodz,Poland;[2]Department of Bioorganic Chemistry,Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences, Sienkiewicza 112,90-363 Lodz,Poland;[3]Ⅱ Department of Cardiology,Medical University of Lodz,1/5 Kniaziewicza St,91-347 Lodz,Poland

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第43期,共9页

基　　金：Supported by The Ministry of Science and Higher Education in Poland project N 402 307336 for 2009-2011 to Nawrot B and No.2 P05B 117 28 of Medical University of Lodz,Poland(toStec-Michalska K 2008) 摘　　要：AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori(H pylori)infection,bacterial cytotoxicity,topography and gender. METHODS:The study comprised 40 premenopausal women(19 H pylori positive)and 48 men(17 H pylori positive)with functional dyspepsia.All gastric biopsy specimens revealed normal mucosa or non-atrophic gastritis.Gastric ghrelin concentration was determined by Enzyme linked immunosorbent assay.The cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain reaction. RESULTS:In general,infection with H pylori causedan increase in gastric ghrelin level regardless of gender and stomach topography.Significantly more hormone was present in both,noninfected and H pylori positive female samples,as compared to males.The distribution of bacterial strains showed cagA(+)vacA s1m1 and cagA(-)vacA s2m2 genotypes as the most common infections in the studied population.A tendency to higher ghrelin levels was observed in less cytotoxic (cagA negative)strain-containing specimens from the antrum and corpus of both gender groups(without statistical significance). CONCLUSION:An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients,especially in those infected with cagA(-) strains,can exert a gastroprotective effect. 关键词：幽门螺杆菌消化不良胃粘膜生长素性别地形患者 GHRELIN

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Gastric ghrelin in relation to gender,stomach topography and Helicobacter pylori in dyspeptic patients

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