A better parameter in predicting insulin resistance:Obesity plus elevated alanine aminotransferase

查看全文 作　　者：Ping-Hao [1]then;Jong-Dar [2]Chen;Yu-Cheng [3]Lin

机构地区：[1]Department of family practice, Lo-Sheng Sanatorium, Department of Health, Taipei County 242, Taiwan, China;[2]Department of family medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan, China;[3]Department of Occupational Medicine, Tao- Yuan General Hospital, Department of Health, Tao-Yuan 330, Taiwan, China

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第44期,共6页

摘　　要：AIM:To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS:We enrolled a total of 1308 male workers aged from 22 to 63 years.Data was extracted from the workers'periodic health check-ups in hospitals.All cases were from the community of northern Taiwan. This was a cross-sectional observational study from July to September in 2004.We grouped all cases into four groups,based on the quartile of homeostasis model assessment.The top fourth quartile group was defined as the group with insulin resistance.We performed multivariate logistic regression analysis for the odds ratio of the risk factors for insulin resistance. RESULTS:Compared with metabolic syndrome,the coexistence of both factors had a 4.3-fold(95%CI: 2.7-6.8)increased risk,which was more than metabolic syndrome with a 3.6-fold(95%CI:2.6-5.0)increased risk.The two factors had a synergistic effect.The synergistic index of obesity and elevated alanine aminotransferase(ALT)was 2.1(95%CI:1.01-4.3).CONCLUSION:Obesity and elevated ALT are associatedwith insulin resistance.The effects are synergistic. Coexistence of them is better than metabolic syndrome in predicting insulin resistance. 关键词：胰岛素抵抗谷丙转氨酶肥胖 Logistic回归分析预测代谢综合征丙氨酸转氨酶协同作用

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A better parameter in predicting insulin resistance:Obesity plus elevated alanine aminotransferase

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