Autoantibodies in primary sclerosing cholangitis

查看全文 作　　者：Johannes Roksund [1]Hov;Kirsten Muri [1]Boberg;Tom H [1]Karlsen

机构地区：[1]Medical Department,Rikshospitalet University Hospital

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第24期,共11页

摘　　要：The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker. 关键词：硬化性胆管炎自身抗体自身免疫性嗜中性粒细胞原肌球蛋白

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Autoantibodies in primary sclerosing cholangitis

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