Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats

查看全文 作　　者：Osamah [1]Hussein;Masha [2]Grosovski;Etti [3]Lasri;Sergio [4]Svalb;Uzi [5]Ravid;Nimer [6]Assy

机构地区：[1]Internal Medicine A,Sieff Government Hospital, Safed, Israel;[2]Ort Braude College of Engineering,Karmiel, Israel;[3]Internal Medicine A,Sieff Government Hospital, Safed, Israel Ort Braude College of Engineering,Karmiel, Israel;[4]Department of Pathology, Sieff Government Hospital, Safed, Israel;[5]Newe Ya'ar Research Center, Ministry of Agriculture,Ramat Yeshai, Israel;[6]Internal Medicine A,Sieff Government Hospital, Safed, Israel Liver Unit, Sieff Government Hospital, Safed, Israel Faculty of Medicine,Technion Israel Institute of Technology,Haifa,Israel

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第3期,共8页

摘　　要：AIM: To evaluate the effects of different types of dietary fats on the hepatic lipid content and oxidative stress parameters in rat liver with experimental non-alcoholic fatty liver disease (NAFLD). METHODS: A total of 32 Sprague-Dawley rats were randomly divided into fi ve groups. The rats in the control group (n = 8) were on chow diet (Group 1), rats (n = 6) on methionine choline-defi cient diet (MCDD) (Group 2), rats (n = 6) on MCDD enriched with olive oil (Group 3), rats (n = 6) on MCDD with fish oil (Group 4) and rats (n = 6) on MCDD with butter fat (Group 5). After 2 mo, blood and liver sections were examined for lipids composition and oxidative stress parameters.RESULTS: The liver weight/rat weight ratio increased in all treatment groups as compared with the control group. Severe fatty liver was seen in MCDD + fish oil and in MCDD + butter fat groups, but not in MCDD and MCDD + olive oil groups. The increase in hepatic triglycerides (TG) levels was blunted by 30% in MCDD + olive oil group (0.59 ± 0.09) compared with MCDD group (0.85 ± 0.04, P < 0.004), by 37% compared with MCDD + fi sh oil group (0.95 ± 0.07, P < 0.001), and by 33% compared with MCDD + butter group (0.09 ± 0.1, P < 0.01). The increase in serum TG was lowered by 10% in MCDD + olive oil group (0.9 ± 0.07) compared with MCDD group (1.05 ± 0.06). Hepatic cholesterol increased by 15-fold in MCDD group [(0.08 ± 0.02, this increment was blunted by 21% in MCDD + f ish oil group (0.09 ± 0.02)]. In comparison with the control group, ratio of long-chain polyunsaturated fatty acids omega-6/ 关键词：脂肪肝脂质脂肪酸治疗方法代谢障碍

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Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats

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