Risk factors of gastric cancer specific for tumor location and histology in Cali,Colombia

查看全文 作　　者：Francia [1]Campos;Gabriel [2]Carrasquilla;Chihaya [1]Koriyama;Mauricio [3]Serra;Edwin [4]Carrascal;Tetsuhiko [5]Itoh;Mitsuharu [6]Nomoto;Suminori [1]Akiba

机构地区：[1]Depart-ment of Epidemiology and Preventive Medicine, Kagoshima Uni-versity Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan;[2]Department of Microbiology, Faculty of Health Sciences, Universidad del Valle, San Fernando, Cali, Co-lombia;[3]Health Division, FES Foundation, Cali, Colom-bia;[4]Department of Pathology, Faculty of Health Sciences, Universidad del Valle, San Fernando, Cali, Colombia;[5]Kaisei-en, Geriatric Health Services Facility, 551 Akasegawa, Akune, Kagoshima, Japan;[6]Department of Human Pathology, Kagoshi-ma University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第36期,共8页

基　　金：Supported by Grants-in-Aid for Scientific Research on Priority Areas of the Ministry of Education, Culture, Sports, Science and Technology, Japan, No. 12218231 and 17015037 摘　　要：AIM: To examine histology- and tumor-location specific risk factors of gastric cancer (GC). METHODS: This was a case-control study. The study subjects were 216 GC patients newly diagnosed during the period 2000-2002 and 431 controls selected from non-cancer patients matching in age, gender, and hospital. We obtained information on lifestyles, dietary habits, and others by a questionnaire. RESULTS: The subjects who were not eldest among his/her siblings were at a slightly elevated GC risk (OR 1.3; 95% CI 0.8-2.0). Salting meals before tasting was related to an increased GC risk (OR 3.5; 95% CI 1.6- 7.3). Frequent consumptions of fruits (OR 0.3; 95% CI 0.1-1.0) and vegetables (OR 0.3; 95% CI 0.1-1.0) were related to decreased GC risks. On the other hand, frying foods (OR 1.9; 95% CI 1.0-3.6) and cooking with coal (OR 1.8; 95% CI 1.3-2.6) were related to increased GC risks. Neither Lauren’s histological classification (intestinal and diffuse types) nor tumor location significantly affected those associations except birth order. The subjects who were not eldest among his/her siblings had an increased risk of GCs in the distal and middle thirds, and their ORs were 1.7 (95% CI 1.0-2.8) and 1.9 (95% CI 0.8-4.3), respectively. The corresponding OR in the upper third stomach was 0.3 (95% CI 0.1-0.9). The differences of those three ORs were statistically significant (P = 0.010). CONCLUSION: The present study shows that birth or- der, salt intake, consumption of fruits and vegetables, the type of cooking, and cigarette smoking are related to GC risk. In histology and tumor-location specific analy- ses, non-eldest person among their siblings is related to an increased GC risk in the distal and middle thirds of the stomach, and is related to a decreased GC risk in the cardia. 关键词：胃癌组织学哥伦比亚病理机制

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Risk factors of gastric cancer specific for tumor location and histology in Cali,Colombia

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